Photoacoustic probes for real-time tracking of endogenous H2S in living mice.

Photoacoustic probes for real-time tracking of endogenous H2S in living mice† †Electronic supplementary information (ESI) available: Procedures for the synthesis of BODPA, living mice imaging, characterization data, and supplementary figures. See DOI: 10.1039/c6sc04703c Click here for additional data file.

A highly selective and sensitive near-infrared fluorescent probe for imaging of hydrogen sulphide in living cells and mice

Hydrogen sulphide (H2S), the third endogenous gaseous signalling molecule, has attracted attention in biochemical research. The selective detection of H2S in living systems is essential for studying its functions. Fluorescence detection methods have become useful tools to explore the physiological roles of H2S because of their real-time and non-destructive characteristics. Herein we report a ne...

Semiconducting Polymer Nanoparticles as Photoacoustic Molecular Imaging Probes in Living Mice

Photoacoustic imaging holds great promise for the visualization of physiology and pathology at the molecular level with deep tissue penetration and fine spatial resolution. To fully utilize this potential, photoacoustic molecular imaging probes have to be developed. Here, we introduce near-infrared light absorbing semiconducting polymer nanoparticles as a new class of contrast agents for photoa...

Chemiluminescent probes for imaging H2S in living animals† †Electronic supplementary information (ESI) available: Detailed experimental procedures, characterization of compounds, computational methods, optimized geometries, atomic charges, supplementary figures, and replicate images. See DOI: 10.1039/c4sc03516j Click here for additional data file.

Hydrogen sulphide (H2S) is an endogenous mediator of human health and disease, but precise measurement in living cells and animals remains a considerable challenge. We report the total chemical synthesis and characterization of three 1,2-dioxetane chemiluminescent reaction-based H2S probes, CHS-1, CHS-2, and CHS-3. Upon treatment with H2S at physiological pH, these probes display instantaneous ...

Reaction-Based Semiconducting Polymer Nanoprobes for Photoacoustic Imaging of Protein Sulfenic Acids.

Protein sulfenic acids play a key role in oxidative signal transduction of many biological and pathological processes; however, current chemical tools rely on visible fluorescence signals, limiting their utility to in vitro assays. We herein report reaction-based semiconducting polymer nanoprobes (rSPNs) with near-infrared absorption for in vivo photoacoustic (PA) imaging of protein sulfenic ac...